Background: Ficus racemosa (Family: Moraceae) is traditionally used in various skin
diseases, cuts, acute and chronic wounds and burns. Hence, the present study has
been designed to evaluate the burn healing potential of Ficus racemosa leaves.
Methodology: In present study Ficus racemosa leaves extract was given in the form of transdermal patch. For which the Ficus racemosa leaves extracted with ethanol and obtained extract was incorporated in chitosan polymer to make patch. 5 and 10% doses have been selected for treatment. Dermal burn wound model was used to determine burn healing activity. Wistar albino rats of either sex weighing between 180-200 g were selected for the study. Burn wound was created by heating
aluminum metal rod at 85°C and held it on the shaved back of rats. Along with this, hydroxyproline level and histopathological study also carried out to support
experimental results. Percentage wound contraction in burn model was significantly (p<0.01) increases in groups treated with 5% patch (95.41%) and 10% patch (98.52%) as compared to control (86.32%). Standard, 5 and 10% treated animals showed complete epithelization in 18, 21 and 19 days, respectively. Hydroxyproline level increase significantly (p<0.01) in 5% (65.45 mg g-1 tissue) and 10% (80.35 mg g-1 tissue) patches as compared to control (39.26 mg g-1 tissue). Histopathological study showed better regeneration of skin as compared to control. The Ficus racemosa leaves extract as transdermal patch have significant
burn healing activity and further study on active fraction responsible for activity is needed.
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Research 
Effect of Transdermal Patch of Ficus racemosa Leaves Activity in the Rat
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